The Codetta Bio Concerto™ system enables rapid, high-throughput analysis — processing up to 24 samples across three chips in a single 3-hour run. With microbead-based target capture, no serial dilutions are needed. Automated imaging, onboard quantification, and integrated data analysis ensure seamless, end-to-end performance for fast, reliable results. Discover our simple and efficient workflow below:
Traditional immunoassays rely on detection antibody (dAb) mixes that allow cross-reaction, limitingmultiplexing capabilities and often forcing researchers to use single-plex analysis. Codetta Bio’s noise-canceling technology eliminates non-specific signals, enabling highly sensitive assays with exceptionalspecificity—even in complex, multiplex environments.
Fluorescently encoded microbeads provide a stable surface for both capture antibodies as well as one of the primers needed for immunoPCR signal transduction.
Once the beads bind their specific target, they are labeled with detection antibodies conjugated to a DNA barcode unique to each analyte.
The beads are loaded and sealed in microwell reaction chambers where they cannot interact with the other beads’ chemistries.
The amplification chemistry from each bead can only amplify the tag specificfor that bead’s analytes. Off target binding is not amplified and no false signal is detectable.
By eliminating non-specific signals, we enable highly sensitive assays that maintain exceptional specificity — even in complex, multiplex environments.
The Codetta Bio Concerto™ system combines digital and analog detection to deliver accurate, reliable quantification across both low and high target concentrations. Whether measuring near the Lower Limit of Quantification or analyzing abundant targets, Concerto™ ensures precise, reproducible multi-omic results.
Using digital PCR detection, we achieve high sensitivity even near the Lower Limit of Quantification(LLoQ), making it ideal for low-concentration target analysis.
Targets per Reaction (TPR) are accurately determined from the positive fraction of all beads for each target, delivering reliable multi-omic measurements with unparalleled precision.
Using analog quantification (qPCR), we achieve precise measurement of high-concentration targets where all or most wells are positive.
Targets per Reaction (TPR) are determined from the average Quantification Cycle (Cq) values of positive beads, delivering reliable and reproducible multi-omic measurements at high concentrations.
By integrating digital and analog detection modalities, we achieve an exceptionally wide dynamic range, enabling precise quantification across multiple orders of magnitude. The below figure demonstrates IL-6 measurement spanning multiple logs, showcasing the power of our approach for capturing both low-and high-abundance targets.
Discover how Codetta Bio™ is transforming multi-omics with cutting-edge technology and expert services, orchestrating your next breakthrough.
Partner with Codetta Bio™ to run a Proof-of-Concept project tailored to your application. Experience our technology through customized service projects designed to meet your unique goals.
Be one of the 50 Concerto Pioneers.We’re opening 50 exclusive pilot project slots post-AACR. Be the first to generate data with the Codetta Bio™ Concerto System.